Yes you can use fresh pasta sheets, the baking time will be lessened. Read your packet instructions.
Use wholemeal pasta sheets, believe me when it's cooked no one notices
You can use ricotta cheese instead of the white sauce. I've used ricotta in the layering and white sauce on the top layer.
Do one layer of meat and one layer of vegetables. Use both layers with vegetables.
I've been known to throw the dregs of my fridges vegetable bin into the meat mix, no one notices.
You can freeze the half portion of tinned tomatoes you don't use for another time.
I use this meat mix for spaghetti bolognaise using 2 whole tins of tomatoes.
Freeze left over lasagne.
Make up the meat sauce, divide into 3 or 4 zip loc bags and freeze. Spaghetti sauce for meals in a hurry.
I've added cooked diced potatoes and carrots to this meat mix and made meat pies.
Use the sauce for a great easy pizza topping, add mushrooms or feta cheese sprinkle with grated cheese.
Play with the proportions and ingredients to your hearts content, it's a very forgiving recipe.